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趙華福

副研究員

PI介紹

博士,副研究員,深圳市海外高層次人才,深圳福田英才,深圳市第二人民醫(yī)院副研究員。現(xiàn)任深圳市抗癌協(xié)會(huì)神經(jīng)腫瘤專業(yè)委員會(huì)委員、中國腫瘤防治聯(lián)盟深圳聯(lián)盟腦轉(zhuǎn)移瘤專業(yè)委員會(huì)委員。2015年獲得香港理工大學(xué)博士學(xué)位,2015-2018年在深圳市第二人民醫(yī)院(工作站)/中山大學(xué)(流動(dòng)站)從事博士后研究。目前主要從事腦膠質(zhì)瘤分子靶向治療的基礎(chǔ)和臨床轉(zhuǎn)化研究工作,負(fù)責(zé)“深圳市醫(yī)管中心醫(yī)學(xué)科技創(chuàng)新平臺(tái)-腦腫瘤精準(zhǔn)醫(yī)療關(guān)鍵技術(shù)研發(fā)和臨床應(yīng)用平臺(tái)”的管理工作。主要研究方向?yàn)閺?fù)發(fā)膠質(zhì)瘤的分子靶向治療和藥物聯(lián)用治療,應(yīng)用多組學(xué)分析技術(shù)闡釋膠質(zhì)瘤復(fù)發(fā)及細(xì)胞侵襲的分子機(jī)制。

主持國家級(jí)和省級(jí)等基金項(xiàng)目共7項(xiàng),包括國家自然科學(xué)基金青年項(xiàng)目1項(xiàng)、廣東省自然科學(xué)基金面上項(xiàng)目2項(xiàng)、中國博士后科學(xué)基金1項(xiàng)、深圳市科創(chuàng)委基礎(chǔ)研究面上項(xiàng)目1項(xiàng)和華南腫瘤學(xué)國家重點(diǎn)實(shí)驗(yàn)室開放課題2項(xiàng)。在Molecular cancer、J Exp Clin Cancer Res、Cancer Cell Int等雜志發(fā)表SCI論文17篇,總影響因子約為62.14,其中以第一作者或通訊作者發(fā)表SCI論文10篇。

教育背景

2012/07-2015/09   香港理工大學(xué),醫(yī)療和社會(huì)科學(xué)學(xué)院,醫(yī)療科技與資訊系,博士,導(dǎo)師:To Shing Shun Tony(屠承信)

2005/09-2007/06   中山大學(xué),生命科學(xué)學(xué)院,動(dòng)物學(xué)系,碩士,導(dǎo)師:張文慶

2001/09-2005/06   武漢大學(xué),生命科學(xué)學(xué)院,生物科學(xué)系,學(xué)士

工作經(jīng)歷

2018/04-至今      深圳市第二人民醫(yī)院,轉(zhuǎn)化醫(yī)學(xué)研究院,副研究員

2015/10-2018/03   深圳市第二人民醫(yī)院,博士后

2008/08-2012/06   廣州軍區(qū)廣州總醫(yī)院,醫(yī)學(xué)實(shí)驗(yàn)科,廣東省骨科矯形技術(shù)與植入材料重點(diǎn)實(shí)驗(yàn)室,研究助理

科研項(xiàng)目

1.國家自然科學(xué)青年基金項(xiàng)目,81602195,PI3Kβ-JNK介導(dǎo)FAK-vinculin調(diào)控膠質(zhì)母細(xì)胞瘤黏著斑復(fù)合體組裝與細(xì)胞遷移的機(jī)制,2017/01-2019/12,17萬元,已結(jié)題,主持。

2.廣東省自然科學(xué)基金基礎(chǔ)研究面上項(xiàng)目,2021A1515012143,PI3Kβ和MLK3抑制劑-殼聚糖納米水凝膠-中性粒細(xì)胞藥物遞送體系協(xié)同抑制惡性膠質(zhì)瘤術(shù)后復(fù)發(fā)的機(jī)制研究,2021/01-2023/12,10萬元,在研,主持。

3.廣東省自然科學(xué)基金自由申請(qǐng)項(xiàng)目,2017A030313531,LanCL2介導(dǎo)Src-Tks5/cortactin信號(hào)軸調(diào)控膠質(zhì)母細(xì)胞瘤侵襲性偽足的組裝和形成的機(jī)制研究,2017/05-2020/05,10萬元,已結(jié)題,主持。

4.中國博士后科學(xué)基金面上項(xiàng)目,2016M592588,PI3Kβ協(xié)同JNK調(diào)控膠質(zhì)瘤細(xì)胞增殖和遷移的機(jī)制研究,2016/05-2018/03,5萬元,已結(jié)題,主持。

5.深圳市科技創(chuàng)新委員會(huì)基礎(chǔ)研究面上項(xiàng)目,JCYJ20160425104157183,MLK3協(xié)同PI3Kβ調(diào)控膠質(zhì)母細(xì)胞瘤黏著斑周轉(zhuǎn)和細(xì)胞遷移的機(jī)制研究,2016/08-2019/07,21萬元,已結(jié)題,主持。

6.華南腫瘤學(xué)國家重點(diǎn)實(shí)驗(yàn)室開放課題,HN2016-09,MLK3協(xié)同PI3Kβ通過FAK-paxillin調(diào)控膠質(zhì)母細(xì)胞瘤黏著斑周轉(zhuǎn)與細(xì)胞遷移的機(jī)制研究,2016/06-2017/06,5萬元,已結(jié)題,主持。

7.華南腫瘤學(xué)國家重點(diǎn)實(shí)驗(yàn)室開放課題,HN2018-11,LanCL2 介導(dǎo)MARCKS 磷酸化調(diào)控膠質(zhì)母細(xì)胞瘤侵襲性偽足形成的機(jī)制研究2018/12-2019/12,5萬元,已結(jié)題,主持。

代表性成果

1.Zhao HF#, Zhou XM#, Wang J, Chen FF, Wu CP, Diao PY, Cai LR, Chen L, Xu YW, Liu J, Li ZY, Liu WL, Chen ZP, Huang GD*, Li WP*. Identification of prognostic values defined by copy number variation, mRNA and protein expression of LANCL2 and EGFR in glioblastoma patients. J Transl Med. 2021;30;19(1):372. (IF=5.531)

2.Zhao HF#, Wu CP#, Zhou XM, Diao PY, Xu YW, Liu J, Wang J, Huang XJ, Liu WL, Chen ZP, Huang GD, Li WP*. Synergism between the phosphatidylinositol 3-kinase p110β isoform inhibitor AZD6482 and the mixed lineage kinase 3 inhibitor URMC-099 on the blockade of glioblastoma cell motility and focal adhesion formation. Cancer Cell Int. 2021;21(1):24. (IF=5.722)

3.Zhao HF, Wang G, Wu CP, Zhou XM, Wang J, Chen ZP, To ST*, Li WP*. A multi-targeted natural flavonoid myricetin suppresses lamellipodia and focal adhesions formation and impedes glioblastoma cell invasiveness and abnormal motility. CNS Neurol Disord Drug Targets. 2018;17(7):557-567. (IF=2.761)

4.Zhao HF, Wang J, Shao W, Wu CP, Chen ZP, To SST*, Li WP*. Recent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical development. Molecular Cancer. 2017; 16(1):100. (IF=7.776)

5.Zhao HF#, Wang J#, Jiang HR, Chen ZP*, To SS*. PI3K p110β isoform synergizes with JNK in the regulation of glioblastoma cell proliferation and migration through Akt and FAK inhibition. J Exp Clin Cancer Res. 2016; 35(1):78. (IF=5.189)

6.Zhao HF, Wang J, To SST*. The phosphatidylinositol 3-kinase/Akt and c-Jun N-terminal kinase signaling in cancer: alliance or contradiction? (review). Int J Oncol. 2015; 47(2): 429-436. (IF=3.018)

7.Zhao HF, Li M, Li LM, Yang XM, Lan GB, Zhang Y*. MiR-133b is down-regulated in human osteosarcoma and inhibits osteosarcoma cells proliferation, migration and invasion, and promotes apoptosis. PloS one. 2013; 8(12):e83571. (IF=3.5328)

8.Wu CP#, Wu P#, Zhao HF#(共同一作), Liu WL*, Li WP*. Clinical applications of and challenges in single-cell analysis of circulating tumor cells.DNA & Cell Biology. 2018; 37(2):78-89. (IF=2.918)

9.Wang W#*, Zhao HF#(共同一作), Yao TF, Gong H. Advanced development of ErbB family-targeted therapies in osteosarcoma treatment. Invest New Drugs. 2019;37(1):175-183. (IF=3.534)

10.Wu J#, Su HK#, Yu ZH#, Xi SY, Guo CC, Hu ZY, Qu Y, Cai HP, Zhao YY, Zhao HF, Chen FR, Huang YF, To STT, Feng BH, Sai K*, Chen ZP*, Wang J*. Skp2 modulates proliferation, senescence and tumorigenesis of glioma. Cancer Cell Int. 2020; 20:71.(IF=4.175)

11.Xu YW#, Liao CP#, Liu RL#, Liu J, Chen ZP, Zhao HF, Li ZY, Chen L, Wu CP, Tan H, Liu WL*, Li WP*. IRGM promotes glioma M2 macrophage polarization through p62/TRAF6/NF-κB pathway mediated IL-8 production. Cell Biol Int, 2019;43(2):125-135.

12.Xu YW#, Liu RL#, Liao CP#, Liu J, Zhao HF, Li ZY, Liu WL, Chen L, Wu CP, Tan H, Chen ZP, Xie N*, Li WP*. High expression of immunity-related GTPase family M protein in glioma promotes cell proliferation and autophagy protein expression.Pathol Res Pract. 2019; 215(1):90-96.

13.Liu J#, Zhou Q#, Wu CP#, Xu YW, Liu WL, Zhao HF, Li WP*. SPHK2 protein expression, Ki-67 index and infiltration of tumor-associated macrophages (TAMs) in human glioma. Histology And Histopathology, 2018, 33(9): 987-994.

14.Wang J, Su HK, Zhao HF, Chen ZP*, To ST*. Progress in the application of molecular biomarkers in gliomas. BBRC. 2015; 465(1):1-4. (IF=2.371)

15.Wang J, Zhao YY, Li JF, Guo CC, Chen FR, Su HK, Zhao HF, Long YK, Shao JY, To SST*, Chen ZP*. IDH1 mutation detection by droplet digital PCR in glioma. Oncotarget. 2015; 6(37):39651-60. (IF=5.0079)

16.Wang G*, Wang JJ, Wu W, Tony To SS, Zhao HF, Wang J. Advances in lipid-based drug delivery: enhancing efficiency for hydrophobic drugs. Expert Opin Drug Deliv. 2015; 5:1-25. (IF=5.434)

17.Wang G*, Wang JJ, Zhao HF, Wang J, Tony To SS. The role of Myc and let-7a in glioblastoma, glucose metabolism and response to therapy. Arch Biochem Biophys. 2015;580:84-92. (IF=2.8069)

18.Wang G*, Wang JJ, To SST, Zhao HF, Wang J. Role of SIRT1-mediated mitochondrial and Akt pathways in glioblastoma cell death induced by Cotinus coggygria flavonoid nanoliposomes. Int J Nanomedicine, 2015; 10: 5005-5023. (IF=4.32)

獲獎(jiǎng)情況

王剛,王俊杰,趙華福,李菲,杜麗,關(guān)銳。具有調(diào)控糖代謝途徑關(guān)鍵靶點(diǎn)的黃酮及其遞藥系統(tǒng)抗膠質(zhì)瘤作用機(jī)制,上海市藥學(xué)會(huì),上海藥學(xué)科技獎(jiǎng)三等獎(jiǎng),2019。