今晚新澳门9点35分开奖结果,49图库资料大全,澳门一肖中100%期期准海南特区号,2025澳门天天开好彩大全53期

Chen Shi

Positions:

Professor

Dean of Shenzhen Translational Medicine Research Institute

Distinguished Professor at the First Affiliated Hospital of Shenzhen University and Shenzhen Second People's Hospital

Director of Shenzhen Key Laboratory of Microbial Genome Modification and Application

Honors and Awards:

Fellow of the American Academy of Microbiology

Recipient of the National Science Fund for Distinguished Young Scholars

Principal Investigator for major international cooperation projects and general projects of the National Natural Science Foundation

Chief Scientist of Major Projects, Ministry of Science and Technology

Research Interests:

Medical Microbiology

Chemical Biology

Precision Medicine

Synthetic Biology

Drug Discovery

As corresponding or co-corresponding author, Chen Shi has published in high-impact journals including:

Nature Catalysis

Proceedings of the National Academy of Sciences (PNAS)(3 papers)

Nature Communications(4 papers)

Advanced Materials

Advanced Science(3 papers)

Advanced Functional Materials

Cell Death & Differentiation

Angewandte Chemie International Edition

Autophagy

Annual Review of Microbiology

Clinical Microbiology Reviews

FEMS Microbiology Reviews

Trends in Cell Biology

Biotechnology Advances

Medicinal Research Reviews

Molecular Neurodegeneration

Theranostics(2 papers)

Protein & Cell

Cell Death & Disease

mBio(4 papers)

Analytical Chemistry

Professional Service:

Member of the International Committee of the International Chemical Biology Society

Former Vice Chair of the Microbial Genetics Professional Committee of the Chinese Society for Genetics

Former Associate Editor of Microbiological Researchand BMC Systems Biology

Editorial Board Member of mLife, Engineering Microbiology, and others

Master's Degree: Biotechnology Integrated Bachelor's-Master's Program, Huazhong Agricultural University

Ph.D.: Shanghai Jiao Tong University

During Ph.D., participated in a collaborative exchange program at Korea Advanced Institute of Science and Technology (KAIST)

Postdoctoral and Academic Experience:

Conducted postdoctoral research at the Massachusetts Institute of Technology (MIT)

Engaged in research work at Harvard University

Served as a faculty member at the School of Pharmacy, Wuhan University

1. Genome Modification, Editing, and Synthetic Biology

Utilizing cutting-edge synthetic biology technologies, we precisely identify, modify, and edit the genomes of cells or pathogens. By identifying the host defense mechanisms against viruses or pathogens, and integrating epigenetics, genomics, and proteomics, we develop specifically designed engineered cells. We analyze how these epigenetic modifications or genome alterations impact cellular activities or pathogen infectivity, and elucidate their effects on superbugs.

2. Design and Modification of Innovative Drugs

Based on the mechanisms of drug synthesis and the understanding of the pathogenic mechanisms of major diseases such as viruses, neurological disorders, and cancers, we conduct comprehensive pathological analyses to rationally select and design potential drugs. Using advanced technologies in synthetic biology, genome editing, genetic engineering, protein engineering, metabolic engineering, and combinatorial biosynthesis, we optimize and modify these potential drugs. We develop corresponding biomaterials, innovative drugs, mRNA vaccines, and therapeutic methods, aiming to improve performance and achieve clinical applicability.

1.Susu Jiang^#, Chao Chen^#, Wanqiu Huang, Yue He, Xuan Du, Yi Wang, Hongda Ou, Zixin Deng, Congrui Xu, Lixu Jiang, Lianrong Wang, Shi Chen*. A widespread phage-encoded kinase enables evasion of multiple host antiphage defense systems. Nature Microbiology, 2024, 9(12); 3226-3239; DOI: 10.1038/s41564-024-01851-2. (https://rdcu.be/dZiTu)

2.Tianchen An^#, Qian Tan^#, Lixu Jiang, Li Liua, Xing Jiang, Liying Liu, Xiaofei Chang, Xihao Tian, Zixin Deng, Shuai Gao, Lianrong Wang*, Shi Chen*. A DNA phosphorothioation pathway via adenylated intermediate modulates Tdp machinery. Nature Chemical Biology, 2025, DOI: 10.1038/s41589-024-01832-w. (https://rdcu.be/d6qIz)

3.Dan Wu^#, Yaqian Tang, Siwei Chen, Yue He, Xiaofei Chang, Wenzhong Zheng, Zixin Deng, Zhiqiang Li, Lianrong Wang*, Geng Wu*, Shi Chen*. The functional coupling between restriction and DNA phosphorothioate modification systems underlying the DndFGH restriction complex. Nature Catalysis. 2022, December, 5, 1131–1144. (https://rdcu.be/c1f5X)

4.Xiaolin Xiong, Geng Wu, Yue Wei, Liqiong Liu, Yubing Zhang, Rui Su, Xianyue Jiang, Mengxue Li, Haiyan Gao, Xihao Tian, Yizhou Zhang, Li Hu, Si Chen, You Tang, Susu Jiang, Ruolin Huang, Zhiqiang Li, Yunfu Wang, Zixin Deng, Jiawei Wang, Peter C. Dedon, Shi Chen, Lianrong Wang*. SspABCD-SspE is a phosphorothioation-sensing bacterial defense system with broad antiphage activities, Nature Microbiology, 2020, July, 5: 917-928. DOI: 10.1038/s41564-020-0700-6.(https://rdcu.be/b3qqS)

5.Chao Chen#, Lianrong Wang#, Si Chen, Xiaolin Wu, Meijia Gu, Xi Chen, Susu Jiang, Yunfu Wang Zixin Deng, Peter C. Dedon, Shi Chen*. Convergence of DNA methylation and phosphorothioation epigenetics in bacterial genomes. Proc Natl Acad Sci U S A, 2017, 114(17): 4501–4506. doi: 10.1073/pnas.1702450114.

6.Lei Xiong#, Siyi Liu#, Si Chen#, Yao Xiao#, Bochen Zhu, Yali Gao, Yujing Zhang, Beibei Chen, Jie Luo, Zixin Deng, Xiangdong Chen, Lianrong Wang, Shi Chen*. A new type of DNA phosphorothioation-based antiviral 1 system in archaea. Nature Communications, 2019, 10:1688 | https://doi.org/10.1038/s41467-019-09390-9.

7.Tong Tong#, Si Chen#, Lianrong Wang#, You Tang#, Jae Yong Ryu, Susu Jiang, Xiaolin Wu, Chao Chen, Jie Luo, Zixin Deng, Zhiqiang Li, Sang Yup Lee*, Shi Chen*. Occurrence, evolution, and functions of DNA phosphorothioate epigenetics in bacteria, Proc Natl Acad Sci U S A, 2018, 115(13): 2988-2996. doi:10.1073/pnas.1721916115.

8.Haiyan Gao#, Xinqi Gong#, Jinchuan Zhou, Yubing Zhang, Jinsong Duan, Yue Wei, Liuqing Chen, Zixin Deng, Jiawei Wang, Shi Chen*, Geng Wu *, Lianrong Wang*. Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE. Nature Communications, 2022, November, 13:6773.

9.Yajie Wang, Yuting Yang, Ying Cai, Ayikaimaier Aobulikasimu, Yuexin Wang, Chuanwei Hu, Zhikang Miao, Yue Shao, Mengna Zhao, Yue Hu, Chang Xu, Xinjun Chen，Zhiqiang Li, Jincao Chen, Lianrong Wang*, Shi Chen*. Endo‐Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1‐Null Rat Hippocampus. Advanced Science, 2024, 11(41): 2407709, doi.org/10.1002/advs.202407709.

10.Ming-Yu Wu#, Luojia Chen#, Qingrong Chen, Rui Hu, Xiaoyu Xu, Yifei Wang, Jie Li, Shun Feng, Changjiang Dong, Xiao-Lian Zhang, Zhiqiang Li,Lianrong Wang*, Shi Chen*, Meijia Gu*. Engineered Phage with Aggregation-Induced Emission Photosensitizer in Cocktail Therapy against Sepsis. Advanced Materials. 2023, 35, 2208578. DOI: 10.1002/adma.202208578.

11.Xuan Zou, Xiaohong Xiao, Ziran Mo, Yashi Ge, Xing Jiang, Ruolin Huang, Mengxue Li, Zixin Deng, Shi Chen*, Lianrong Wang*, Sang Yup Lee*. Systematic strategies for developing phage resistant Escherichia coli strains. Nature Communications, 2022, 13: 4491.

12.Luojia Chen#, Ming-Yu Wu#,*, Si-Ling Chen#, Rui Hu, Yifei Wang, Weijuan Zeng, Shun Feng, Min Ke*, Lianrong Wang*, Shi Chen*, Meijia Gu*. The Guardian of Vision: Intelligent Bacteriophage-Based Eyedrops for Clinical Multidrug-Resistant Ocular Surface Infections. Advanced Materials, 2024, 36(28）: 2407268.doi.org/10.1002/adma.202407268.

13.Pengqing Nie, Cheng Zhang, Fengyi Wu, Shi Chen,* Lianrong Wang*. The Compromised Fanconi Anemia Pathway in Prelamin A-Expressing Cells Contributes to Replication Stress-Induced Genomic Instability. Advanced Science, 2024, 11(30): 2307751. DOI: 10.1002/advs.202307751.

14.Ming-Yu Wu#, Xiaoyu Xu#, Rui Hu#, Qingrong Chen, Luojia Chen, Yuncong Yuan, Jie Li, Li Zhou, Shun Feng,Lianrong Wang*, Shi Chen*, Meijia Gu*. A membrane-targeted photosensitizer prevents drug resistance and induces immune response in treating Candidiasis. Advanced Science. 2023, e2207736. DOI: 10.1002/advs.202207736.

15.Yaqian Tang#, Dan Wu#, Yueying Zhang, Xuan Liu, Hui Chu, Qian Tan, Lixu Jiang, Shi Chen*, Geng Wu* and Lianrong Wang*. Molecular basis of the phosphorothioation-sensing antiphage defense system IscS–DndBCDE–DndI. Nucleic Acids Research. 2024, 52(22): 13594–13604. doi.org/10.1093/nar/gkae1133.

16.Lianrong Wang*,Yaqian Tang, Zixin Deng,Shi Chen*. DNA Phosphorothioate Modification Systems and Associated Phage Defense Systems. Annual Review of Microbiology,2024,78:447-462. DOI.org/10.1146/annurev-micro-041222-014330.

17.Bo Cao#, Chao Chen#, Michael S. DeMott#, Qiuxiang Cheng, Tyson A. Clark, Xiaolin Xiong, Xiaoqing Zheng, Vincent Butty, Stuart S. Levine, George Yuan, Matthew Boitano, Khai Luong, Yi Song, Xiufen Zhou, Zixin Deng, Stephen W. Turner, Jonas Korlach, Delin You*, Lianrong Wang*, Shi Chen*, Peter C. Dedon. Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences. Nature Communications, 2014, 5, DOI:10.1038/ncomms4951.

18.Yansheng Li, Lianrong Wang*, Shi Chen*. An overview of the progress made in research into the Mpox virus. Medicinal Research Reviews, 2024, Sep 24. DOI: 10.1002/med.22085.

19.Lianrong Wang, Susu Jiang, Chao Chen, Wei He, Xiaolin Wu, Fei Wang, Tong Tong, Xuan Zou, Zhiqiang Li, Jie Luo, Zixin Deng, Shi Chen*. Synthetic genomes: from DNA synthesis to genome design. Angew Chem Int Ed., 2018, 57: 2~11.

20.Meijia Gu#, Xiaoyu Xu#, Ming-Yu Wu#, Chao Chen, Yuncong Yuan, Qingrong Chen, Yidan Sun, Luojia Chen, Chao Shen, Peng Guo, Shujie Liu, Engui Zhao*, Shi Chen*, Sijie Chen*. Simultaneous photodynamic eradication of tooth biofilm and tooth whitening with an aggregation-induced emission luminogen. Advanced Science, 2022, 9, 2106071.

21.Xuemin Liu#, Shengtao Yan, Hongliang Wu, Ming Chen, Hao Dai, Zhenxing Wang, Muyuan Chai, Qingyu Hu, Dongdong Li, Lei Chen, Ruiying Diao, Shi Chen,* Liping Wang,*Xuetao Shi*. Interventional Hydrogel Microsphere Controlled-Releasing Curcumin for Photothermal Therapy against Endometriosis. Advanced Functional Materials, 2024, 34(26): 2315907. DOI: 10.1002/adfm.202315907.

22.Xuan Zou, Ziran Mo, Lianrong Wang,* Shi Chen,* and Sang Yup Lee*. Overcoming Bacteriophage Contamination in Bioprocessing: Strategies and Applications. Small methods, 2024. DOI: 10.1002/smtd.202400932.

23.Yanlian Chen, Zhiqiang Deng, Shuai Jiang, Qian Hu, Haiying Liu, Zhou Songyang, Wenbin Ma, Shi Chen*, Yong Zhao*. Human cells lacking coilin and Cajal bodies are proficient in telomerase assembly, trafficking and telomere maintenance. Nucleic Acids Research, 2014, 1-11.DOI: 10.1093/nar/gku1277.

24.Lianrong Wang, Shi Chen*, Kevin L. Vergin, Stephen J. Giovannoni, Simon W. Chan, Michael S. DeMott, Koli Taghizadehe, Otto X. Cordero, Michael Cutler, Sonia Timberlake, Eric J. Alm, Martin F. Polz, Jarone Pinhassi, Zixin Deng, Peter C. Dedon*. DNA phosphorothioation is widespread and quantized in bacterial genomes. Proc Natl Acad Sci U S A, 2011, 108 (7): 2963-2968.

25.Wenzhong Zheng#, Kexin Wang#, Yachen Wu#, Ge Yan, Chi Zhang, Zhiqiang Li, Lianrong Wang*, Shi Chen*.C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α. Theranostics, 2022, Oct 17, 12(17):7289-7306. DOI: 10.7150/thno.76138.

26.Yachen Wu#, Wenzhong Zheng, Guofeng Xu, Lijun Zhu, Zhiqiang Li, Jincao Chen, Lianrong Wang*,Shi Chen*. C9orf72 controls hepatic lipid metabolism by regulating SREBP1 transport. Cell Death & Differentiation, 2024, 31(8): 1070–1084. DOI: 10.1038/s41418-024-01312-7.

27.Zhiqiang Deng, Junghyun Lim, Qian Wang, Kerry Purtell, Shuai Wu, Gloria M. Palomo, Haiyan Tan, Giovanni Manfredi, Yanxiang Zhao, Junmin Peng, Bo Hu, Shi Chen*, Zhenyu Yue*. ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/ NRF2 anti-oxidative stress pathway. Autophagy, 2019,16(5): 917-931. DOI: 10.1080/15548627.2019.1644076.

28.Fang Wang, Runhua Han, Shi Chen*. An overlooked and underrated endemic mycosis - Talaromycosis and the pathogenic fungus Talaromyces marneffei. Clinical Microbiology Reviews, 2023, 36(1):e0005122.

29.Yajie Wang#, Zhikang Miao#, Chang Xu, Ying Cai, Yuting Yang, Yue Hu, Mengna Zhao, Yue Shao, Zhiqiang Li, Jincao Chen, Shi Chen*, Lianrong Wang*. Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats. Cell Death & Disease, 2023 May 13;14(5):325. DOI: 10.1038/s41419-023-05846-5.

30.Huang Q, Wang F, Yuan C, He Z, Rao L, Cai B, Chen B, Jiang S, Li Z, Chen J, Liu W, Guo F, Ao Z*, Shi Chen*, Zhao X*. Gelatin nanoparticle-coated silicon beads for density-selective capture and release of heterogeneous circulating tumor cells with high purity. Theranostics, 2018, 8(6): 1624~1635.

31.Deng Z, Purtell K Lachance V, Wold M, Shi Chen*, Yue Z*. Autophagy Receptors and Neurodegenerative Diseases. Trends in Cell Biology, 2017, 27(7).491~504. DOI: 10.1016/j.tcb.2017.01.001.

32.Fei Wang#, Lianrong Wang#, Xuan Zou, Suling Duan, Zhiqiang Li, Zixin Deng, Jie Luo, Sang Yup Lee*, Shi Chen*. Advances in CRISPR-Cas systems for RNA targeting, tracking and editing. Biotechnology Advances. 2019, Mar, 37(5):708-729. DOI: 10.1016/j.biotechadv.2019.03.016.

33.Lianrong Wang, Susu Jiang, Zixin Deng, Peter Dedon, Shi Chen*. DNA phosphorothioate modification–a new multi-functional epigenetic system in bacteria. FEMS Microbiology Reviews. 2019, 43(2), 109–122.  DOI: 10.1093/femsre/fuy036.

34.Meijia Gu#*, Luojia Chen#, Rui Hu, Qingrong Chen, Jianbo Liu*, Lianrong Wang*, Shi Chen*. Aggregation-induced emission: recent applications in infectious diseases. SCIENCE CHINA Chemistry, 2023 Oct, 66: 2986–3005. DOI: 10.1007/s11426-023-1825-7.

35.Zhiqiang Deng, Patricia Sheehan, Shi Chen*, Zhenyu Yue*. Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease? Molecular Neurodegeneration, 2017, 12:90. DOI: 10.1186/s13024-017-0232-6.

36.Xuan Zou#, Lianrong Wang#, Zhiqiang Li, Jie Luo, Yunfu Wang, Zixin Deng, Shiming Du, Shi Chen*. Genome engineering and modification toward synthetic biology for the production of antibiotics. Medicinal Research Reviews, 2018, 38(1): 229~260.

37.Shi Chen*, Lianrong Wang, Zixin Deng*. Twenty years hunting for sulfur in DNA. Protein & Cell, 2010, 1(1): 14-21.

We warmly welcome passionate, resilient, enterprising, idealistic, and diligent master's and doctoral students to join us in our exploration.

We are offering high-salary positions for 8 postdoctoral researchers in the following areas: Structural Biology, mRNA Vaccines, Artificial Intelligence/Bioinformatics, Epigenetics, Microbiology, Synthetic Biology, Nano Biomaterials, Cell Biology, Biochemistry and Molecular Biology, Immunology, and Innovative Drug Design and Modification.

For more details, please visit: http://piqzwsk.cn/zhyxyjy/znxs/bshjkyzlzp/content/post_823962.html

Honors and Awards

2022

Chief Scientist of the National Key R&D Program, Ministry of Science and Technology

2020

Fellow of the American Academy of Microbiology

2019

National Science Fund for Distinguished Young Scholars, National Natural Science Foundation of China

2018

Leading Talent in Science and Technology Innovation, Ministry of Science and Technology

2017

Leading Talent in Medicine, Hubei Province

2016

Outstanding Academic Paper Award, Annual Meeting of the Chinese Society for Microbiology

2015

First Prize in Natural Science, Higher Education Science Research Excellent Achievement Award (6th place)

2014

Outstanding Academic Paper Award, Annual Meeting of the Chinese Society for Microbiology

2013

Distinguished Expert, Hubei Province

2012

Chutian Scholar Distinguished Professor, Hubei Province

2008

Second Prize, National Natural Science Award (5th place)

2007

Second Prize, Shanghai Excellent Invention Award Selection Competition

Bronze Medal, 5th Tan Kah Kee Young Inventors Award (Shanghai), Tan Kah Kee Foundation, Singapore

2006

Outstanding Graduate Thesis Award, Shanghai

2004

First Prize, Science and Technology Progress Award, Shanghai (4th place)

Model of the New Long March Assault Troop, Shanghai

Silver Medal, 2nd Tan Kah Kee Young Inventors Award (Shanghai), Tan Kah Kee Foundation, Singapore

Meiji Dairies Life Science Excellence Award

Shanghai-Unilever Research and Development Fund Scholarship