Innovative Drug Development and Precision Health Products with Medicinal Food Homology
Focusing on nano-targeted drug delivery technology, traditional Chinese medicine (TCM) chemistry, chemical synthesis, computer-aided design, high-throughput screening, pharmacology, and novel formulation technologies, we aim to address major challenging diseases such as Alzheimer's disease and Parkinson's disease. We establish relevant cell and animal models to screen for active small molecule compounds in TCM, developing high-efficiency, low-toxicity nano-grade TCM microcapsules with targeted properties. This comprehensive research includes quality standards, drug stability, preclinical efficacy, and safety studies, forming a technology platform for innovative drug development for elderly disease prevention and treatment with distinctive advantages. Our lab specializes in brain-targeted anti-Alzheimer's nano technology and drug delivery systems with numerous patents and provincial and ministerial awards. We have published 93 papers, filed and obtained 92 patents, and are equipped with over 6 million RMB worth of equipment, including HPLC, preparative liquid chromatography, supercritical extraction devices, enzyme markers, drug stability chambers, tablet presses, intelligent dissolution testers, a supercomputing platform for computer-aided drug design, freeze dryers, TCM pulverizers, muffle furnaces, and UV spectrophotometers.
Research Directions and Technology Introduction:
Development of New TCM Drugs and In-hospital TCM Preparations:
Based on clinical efficacy, develop in-hospital TCM preparations to enhance the technical content and socioeconomic benefits of TCM clinical medication.
Develop modern compound TCM drugs based on relevant scientific research results and technical invention patents.
Actively engage in the development and application of classic TCM prescription formulations under national policy.
Nano-Targeted Drug Delivery Technology and Active TCM Monomer Drug Research:
Utilizing existing technological advantages, conduct research and development of nano-brain-targeting medical biotechnology.
Establish new nano-brain-targeting techniques and develop innovative nano-brain-targeting drugs.
For major challenging diseases like Alzheimer's and Parkinson's, establish relevant cell and animal models to screen active small molecule TCM compounds.
Develop high-efficiency, low-toxicity, and targeted nano-grade TCM microcapsules, conducting systematic quality standards, drug stability, preclinical efficacy, and safety studies to develop a series of nano natural TCM new drugs.
Computer-Aided Drug Molecular Design and High-Throughput Screening:
Establish a technology platform for computer-aided drug molecular design and high-throughput screening.
Select key drug targets for major chronic diseases to conduct computer-aided molecular design and high-throughput screening, advancing the development of innovative new drugs.
Total Synthesis of Natural Products and First-Class New Drug Development:
Leveraging our expertise in TCM chemistry and total synthesis of natural products, combined with existing research results and invention patents, perform total synthesis research of scarce, highly active natural products and computer-designed compounds.
Innovate in technical fields and conduct multi-drug resistance research, developing original first-class drugs including peptides, antibody biological drugs, and small molecule chemical drugs with nano-targeted drug delivery technology.
